Table 2.

Tumor response.

	Cohort 1A	Cohort 1B	Cohort 2
	n = 8	n = 9	n = 8
Best overall response, n (%)
Complete response	1 (12.5)	2 (22.2)	3 (37.5)
Partial response	5 (62.5)	2 (22.2)	2 (25.0)
Stable disease	1 (12.5)	2 (22.2)	0 (0.0)
Progressive disease	0 (0.0)	2 (22.2)	1 (12.5)
Not evaluable	1 (12.5)	1 (11.1)	2 (25.0)
Confirmed ORR, % (95% CI)	75.0 (34.9–96.8)	44.4 (13.7–78.8)	62.5 (24.5–91.5)
Confirmed DCR, % (95% CI)	87.5 (47.3–99.7)	66.7 (29.9–92.5)	62.5 (24.5–91.5)
Median DOR, % (95% CI)	7.4 (4.2–NR)	NR (10.4–NR)	NR (NR–NR)

Abbreviations: CI, confidence interval; DCR, disease control rate; DOR, duration of response; NR, not reached; ORR, objective response rate.