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In vitro PK parameters
| Parameter | DMH2 | JL5 |
|---|---|---|
| ClearanceINT (mL/min/kg) | 250 | 129 |
| Plasma protein binding | 98.60% | 98.30% |
From: Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer
