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Pharmocokinetics
| Compound | Route | C0/Cmax (ng/mL) | AUClast (hr×ng/mL) | AUCinf (hr×ng/mL) | T1/2 (hr) | CL (mL/min/kg) | Vss (L/kg) |
|---|---|---|---|---|---|---|---|
| DMH2(2) | i.v. | 3,035 | 485 | 487 | 0.95 | 68 | 0.95 |
| p.o. | 684 | 707 | 729 | — | — | — | |
| JL5 | i.v. | 568 | 349 | 381 | 0.57 | 194 | 8.78 |
| p.o. | 1,282 | 1,605 | 1,645 | — | — | — |
From: Novel bone morphogenetic protein receptor inhibitor JL5 suppresses tumor cell survival signaling and induces regression of human lung cancer
