Table 3.

The result of cost ($US) simulation of genetic screening tests for the genetic strategies

Cost items	Costs for population-based screening strategy	% of total cost	Costs for FH-based screening strategy	% of total cost
Genetic counseling and genetic screening BRCA tests	350,420,813	96.36	7,202,469	40.64
Preventive surgical interventions and associated costs	4,280,310	1.18	1,715,237	9.68
Preventive interventions (mammography and annual MRI)	68,157	0.02	27,312	0.15
Total direct medical costs	354,769,280	97.56	8,945,018	50.47
Total direct non-medical costs	8,881,488	2.44	8,777,327	49.53
Total direct medical and non-medical costs	363,650,768	100	17,722,345	100
Number of people entered into the models	2,176,919		2,176,919
Number of high-risk individuals identified	12,271		4,917
Cost per screening	167.05		8.14

*US $1 in 2021 = 230,000 IRR