Table 1.
Diagnostic criteria for Alzheimer disease and cognitive impairment
Probable Alzheimer disease | By criteria of the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA) [6] Dementia by clinical examination, and documented with the Mini-Mental Status Exam (MMSE) and the Short-Blessed functional impairment questionnaire, with progressive deficits in 2 or more cognitive domains. • Absence of other disorders that could account for the progressive dementia symptoms |
Possible Alzheimer disease | By NINCDS-ADRDA criteria : • Dementia, as defined above; • Presence of 1) variations in the onset, presentation or clinical course; - or - 2) other disorder(s) sufficient to produce dementia, but not thought to be the cause of the dementia in this case |
Mild Cognitive Impairment | • Subjective memory complaint • Normal general cognitive function by MMSE • Standard score of -1.5, below the same-age norm, on the long delay free recall item of the California Verbal Learning Test (CVLT) |
Age-Associated Memory Impairment | • Has both Subjective memory complaint and normal general cognitive function by MMSE • And either: 1) Standard score of -1.0, below the norm for 20–24 year- olds, on the long delay free recall item of the CVLT - or - 2) Clinical Dementia Rating score of 0.5 - or - 3) Significant decline from previous performance on cognitive test(s) while still scoring in normal range |