Table 2.
Outcomes per 1000 individuals for efficient screening strategies within the CMOST model
| Strategy | COLs | Non-COL tests | Reduced CRC cases | Reduced CRC deaths | LYG | Patients died of COLs | Years lost due to COLs | Efficiency ratio (ΔCOL/ΔLYG) |
Ratio of additional COLs to LYG |
|---|---|---|---|---|---|---|---|---|---|
| FIT | |||||||||
| FIT, 50–70, 3 | 920 | 6013 | 14 | 7 | 83 | 0.04 | 0.67 | Default | 10.5 |
| FIT, 45–70, 3 | 1068 | 7542 | 16 | 8 | 98 | 0.03 | 0.71 | 9.6 | 10.4 |
| FIT, 40–70, 3a | 1202 | 9064 | 17 | 8 | 105 | 0.05 | 1.05 | 12.7 | 11.0 |
| FIT, 45–70, 2a | 1344 | 10,342 | 19 | 9 | 114 | 0.06 | 1.27 | 13.7 | 11.4 |
| FIT, 40–70, 2 | 1522 | 12,444 | 20 | 9 | 126 | 0.05 | 1.09 | 13.8 | 11.7 |
| FIT, 40–75, 2 | 1685 | 13,954 | 21 | 10 | 133 | 0.06 | 1.22 | 15.4 | 12.3 |
| FIT, 40–80, 2 | 1812 | 15,196 | 21 | 11 | 136 | 0.06 | 1.25 | 16.8 | 13.0 |
| FIT, 40–70, 1a | 2232 | 20,461 | 23 | 11 | 145 | 0.09 | 2.26 | 21.1 | 15.1 |
| FIT, 40–75, 1 | 2476 | 22,938 | 24 | 12 | 151 | 0.10 | 2.25 | 22.7 | 16.1 |
| FIT, 40–80, 1 | 2670 | 24,963 | 24 | 12 | 155 | 0.10 | 2.23 | 24.2 | 16.9 |
| NCPCS | |||||||||
| NCPCS, 50–70, 3 | 1880 | 5585 | 19 | 8 | 93 | 0.07 | 1.32 | Default | 19.6 |
| NCPCS, 40–70, 3 | 2542 | 8294 | 22 | 9 | 119 | 0.1 | 2.35 | 26.0 | 21.0 |
| NCPCS, 40–70, 2 | 3107 | 10,553 | 24 | 10 | 130 | 0.12 | 2.66 | 33.3 | 23.5 |
| NCPCS, 40–70, 1 | 4107 | 14,715 | 25 | 11 | 141 | 0.13 | 3.23 | 46.3 | 28.7 |
| NCPCS, 40–75, 1 | 4565 | 16,440 | 26 | 12 | 145 | 0.15 | 3.32 | 51.7 | 31.1 |
| NCPCS, 40–80, 1 | 4930 | 17,855 | 27 | 12 | 148 | 0.16 | 3.41 | 56.0 | 33.0 |
| RS model | |||||||||
| RS model, 50–70, 3 | 2564 | 4992 | 22 | 10 | 114 | 0.08 | 1.47 | Default | 22.1 |
| RS model, 45–70, 3 | 3054 | 6220 | 24 | 10 | 128 | 0.12 | 2.53 | 34.7 | 23.5 |
| RS model, 40–70, 3 | 3539 | 7475 | 24 | 10 | 138 | 0.11 | 2.60 | 40.6 | 25.3 |
| RS model, 40–75, 3 | 3928 | 8346 | 26 | 11 | 145 | 0.12 | 2.83 | 44.1 | 26.8 |
| RS model, 40–75, 2 | 4543 | 9899 | 26 | 12 | 151 | 0.14 | 3.50 | 53.5 | 29.8 |
| RS model, 40–80, 2 | 4903 | 10,748 | 27 | 12 | 152 | 0.14 | 3.39 | 60.4 | 31.9 |
| RS model, 40–80, 1 | 5901 | 13,325 | 27 | 12 | 154 | 0.20 | 4.73 | 83.1 | 38.0 |
COL Colonoscopy, CRC Colorectal cancer, LYG Life-years gained, FIT Fecal immunochemical test, RS Risk-stratification, NCPCS National Colorectal Polyp Care score; Default, the one with the least LYG and required least colonoscopy, ΔCOL, incremental number of colonoscopies compared with the default strategy, ΔLYG, incremental number of LYG compared with the default strategy. Additional COLs were the difference between efficient strategy and no screening
a Near-efficient strategies