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. 2024 Feb 2;52(3):766–778. doi: 10.1177/03635465231220855

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© 2024 The Author(s)

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — Systemic TXA treatment protects against subchondral bone loss after ACLT. (A) The representative 3-dimensional μCT reconstruction and hematoxylin and eosin staining images of the coronal views of tibial subchondral bone 4 weeks after ACLT (scale bar = 500 μm). Red indicates cut plane. (B) μCT quantitative analysis of tibial subchondral bone for the BV/TV, Tb.N, Tb.Th, and Tb.Sp. The data are expressed as mean ± SD; n = 6-7 per group as indicated (2-way analysis of variance followed by the Tukey post hoc test). *P < .05 for comparisons denoted by bar. μCT, micro−computed tomography; ACLT, anterior cruciate ligament transection; BV/TV, bone volume fraction; OA, osteoarthritis; Tb.N, trabecular number; Tb.Sp, trabecular separation; Tb.Th, trabecular thickness; TXA, tranexamic acid.