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. 2024 Feb 2;52(3):766–778. doi: 10.1177/03635465231220855

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© 2024 The Author(s)

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Systemic TXA treatment inhibits ACLT-induced bone resorption in subchondral bone. (A) Representative images of tibial subchondral bone 4 weeks after ACLT, in which osteoclasts were stained by TRAP. Scale bar = 100 μm. (B) Quantitative analysis of Oc.S/BS and the number of Oc.N/B.Pm. (C) Quantitative analysis of the Ob.S/BS and the number of Ob.N/B.Pm. The data are expressed as mean ± SD; n = 5-7 per group as indicated (2-way analysis of variance followed by the Tukey post hoc test). *P < .05 for comparisons denoted by bar. ACLT, anterior cruciate ligament transection; OA, osteoarthritis; Ob.N/B.Pm, number of osteoblasts per bone perimeter; Ob.S/BS, osteoblast surface per bone surface; Oc.N/B.Pm, number of osteoclasts per bone perimeter; Oc.S/BS, osteoclast surface per bone surface; TRAP, tartrate-resistant acid phosphatase; TXA, tranexamic acid.