Table 4.

Synergistic interaction between fungal crude extract with antibiotics.

Pathogen	Antibiotic	MIC (μg/mL)				FICI	Interpretation
		Extract		Antibiotic
		Alone	Combination	Alone	Combination
MRSA (ATCC 43300)	Oxacillin	3.12 ± 0.05*	1.56 ± 0.05*	50 ± 0.25**	0.78 ± 0.04*	0.5	Synergistic
	Vancomycin	3.12 ± 0.05*	0.39 ± 0.11**	12.5 ± 0.05*	1.56 ± 0.2**	0.24	Synergistic
MRSA (ATCC 700699)	Oxacillin	1.56 ± 0.05**	0.19 ± 0.21*	50 ± 0.15**	1.56 ± 0.2**	0.15	Synergistic
	Vancomycin	1.56 ± 0.05**	0.39 ± 0.25*	12.5 ± 0.25**	3.12 ± 0.04*	0.4	Synergistic
VRE	Oxacillin	6.25 ± 0.25**	3.12 ± 0.11**	50 ± 0.5*	12.5 ± 0.03*	0.7	Indifference
	Vancomycin	6.25 ± 0.25**	1.56 ± 0.11**	12.5 ± 0.21**	3.12 ± 0.03*	0.4	Synergistic

FICI ≤ 0.5: synergy, FICI > 0.5 to 4: indifference, FICI > 4: antagonism, “*” indicates significant differences (*p < 0.05; **p < 0.01) between the treated and the control samples.