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. 2024 Jan 23;9(2):e172702. doi: 10.1172/jci.insight.172702

Figure 3. rIL-13 administration improves functional recovery after MI in adult mice.

Figure 3

(A) Experiment protocol. (B) Fractional shortening shown as percentage of LV end-diastolic diameter (LVEDD). (C) Representative images of Gömöri trichrome staining of mouse heart sections at 28 dpi. Scale bar: 2 mm. (D) Quantification of total scar area summed from 3 serial cardiac sections. (E) Representative images of CD31, WGA, and DAPI of 28 dpi hearts. White box insets indicate zoomed-in regions. (F and G) Quantifications of capillary density and capillary size at the BZ and RZ in 28 dpi heart sections. (H) Representative images of EdU, PCM1, and DAPI in cardiac sections from 28 dpi mice. (I) Quantifications of EdU+PCM1+ cells as a percentage of total PCM1+ cells in BZ and RZ. (J) Survival curves up to 28 dpi after MI. Data are shown as mean ± SD. Each data point represents 1 mouse. *P < 0.05. Interaction of treatment (PBS versus rIL-13) and time effect by 2-way repeated-measures ANOVA and Sidak’s post hoc test at 28 dpi in B. Comparison by unpaired 2-tailed t test in D, F, G, and I. Data were analyzed by Mantel-Cox in J.