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. 2024 Mar 1;14(11):7371–7382. doi: 10.1039/d3ra08360h

Kinetic parameter of rifampicin release.

Release profile Kinetic of rifampicin release
Zero order First order Higuchi Kitazawa Hixon–Crowell
k 0 R 2 k 1 R 2 k 2 R 2 k 3 R 2 k 4 R 2
pH 1.5a 0.1683 0.66 0.0535 0.63 0.5472 0.78 0.0018 0.66 0.0561 0.66
pH 1.5b 0.3158 0.92 0.0408 0.94 0.0408 0.90 0.0036 0.93 0.0036 0.93
pH 6.5 2.1075 0.95 0.0496 0.83 12.192 0.96 0.0496 0.94 0.7025 0.95
a

Profile 1 of rifampicin release (a1) zero order, (b1) first order, (c1) Higuchi, (d1) Kitazawa, and (e1) Hixon–Crowel between 0.5–5 hours of dissolution in Fig. 10.

b

Rifampicin release profile 2 (a2) zero-order, (b2) first-order, (c2) Higuchi, (d2) Kitazawa, and (e2) Hixon–Crowel between 6–15 hours of dissolution in Fig. 11.