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HBOT Mechanism. HBOT increases cellular autophagy, leading to upregulation of AMPK, beclin-1, and LC3I/II proteins. It also downregulates mTOR and p62 proteins. HBOT inhibits phosphorylation of tau protein (Thr181, Thr205) and improves synaptic plasticity by increasing levels of Syn, BDNF, and PSD95 proteins.
