Figure 3.

Empiric antimicrobial strategy for prevention of neuroinvasive Bacillus cereus infections in patients with acute myeloid leukemia. The figure displays the empiric antimicrobial strategy that was initiated at our institution among patients with acute myeloid leukemia for the prevention of neuroinvasive B cereus infection. The strategy was elected to maximize antimicrobial stewardship by ensuring time-limited courses of empiric fluoroquinolone therapy and prompt discontinuation if blood cultures remained negative and there was no evidence of neuroinvasive B cereus infection. Fluoroquinolone therapy was selected given optimal central nervous system penetration and borderline elevated minimum inhibitory concentrations to vancomycin for the organisms isolated at our institution. AML, acute myeloid leukemia.