TABLE 3.
Phosphorylation events regulating mitochondrial calcium homeostasis and MAMs. CDK1, cyclin-dependent kinase 1; GSK3β, glycogen synthase-3 beta; IP3R1 inositol 1,4,5–triphosphate receptor type 1; MCU, mitochondrial calcium uniporter; MICU1, mitochondrial calcium uptake 1; NEK1, NIMA-related kinase 1; PACS-2, phosphofurin acidic cluster sorting protein 2; PTPIP51, protein tyrosine phosphatase interacting protein 51; VDAC1, voltage dependent anion channel type 1.
| Target | Phospho site | Kinase | Associated outcome |
|---|---|---|---|
| VDAC1 | S193 | NEK1 | Suppression of mitochondrial membrane permeabilisation |
| VDAC1 | S12, S103 | GSK3β | Increased sensitivity to endostatin-induced cell death |
| MCU | S92 | PKC | Altered dimerization capacity of MCU tetramers (hypothesis) |
| MICU1 | S124 | AKT | Increase of mitochondrial Ca2+ |
| PACS-2 | S437 | AKT | Prevention of PACS-2’s role in apoptosis |
| IP3R1 | T799 | CDK1/cyclin B | Increase in IP3 binding and Ca2+ release |
| PTPIP51 | T126 | c-Src | Support of correct interaction with 14-3-3 family proteins and PKA |