Table 3.
Geometric Mean Ratio and Its 90% Confidence Interval Between Only Escitalopram Administration and Co-Administration of Escitalopram with Herbal Medicine Stratified by CYP2C19 Phenotype
| Group | Treatment | CYP2C19 Phenotype | Parameters | GeoLSM | GMR (90% CI) | |
|---|---|---|---|---|---|---|
| E | E+A1 | E+A1/E | ||||
| 1 | E vs E+A1 (n=8) | EM | Cmax,ss (ng/mL) | 21.46 | 22.69 | 1.0574 (0.7600–1.4712) |
| AUCtau,ss (h∙ng/mL) | 346.88 | 355.48 | 1.0248 (0.6766–1.5522) | |||
| IM | Cmax,ss (ng/mL) | 23.27 | 27.95 | 1.2013 (0.9634–1.4980) | ||
| AUCtau,ss (h∙ng/mL) | 413.40 | 453.75 | 1.0976 (0.8441–1.4273) | |||
| E vs E+A2 (n=6*) | E | E+A2 | E+A2/E | |||
| EM | Cmax,ss (ng/mL) | 21.46 | 21.38 | 0.9966 (0.6958–1.4276) | ||
| AUCtau,ss (h∙ng/mL) | 346.88 | 334.68 | 0.9648 (0.6256–1.4880) | |||
| IM | Cmax,ss (ng/mL) | 25.86 | 26.92 | 1.0413 (0.6321–1.7153) | ||
| AUCtau,ss (h∙ng/mL) | 439.45 | 483.71 | 1.1007 (0.6499–1.8641) | |||
| 2 | E vs E+A3 (n=9) | E | E+A3 | E+A3/E | ||
| EM | Cmax,ss (ng/mL) | 23.00 | 24.09 | 1.0476 (0.7043–1.5583) | ||
| AUCtau,ss (h∙ng/mL) | 353.64 | 374.10 | 1.0579 (0.6698–1.6708) | |||
| IM | Cmax,ss (ng/mL) | 20.63 | 25.14 | 1.2185 (0.8163–1.8190) | ||
| AUCtau,ss (h∙ng/mL) | 330.42 | 402.84 | 1.2192 (0.7626–1.9490) | |||
| E vs E+A4 (n=9) | E | E+A4 | E+A4/E | |||
| EM | Cmax,ss (ng/mL) | 23.00 | 24.65 | 1.0719 (0.6959–1.6513) | ||
| AUCtau,ss (h∙ng/mL) | 353.64 | 393.18 | 1.1118 (0.6971–1.7731) | |||
| IM | Cmax,ss (ng/mL) | 20.63 | 24.73 | 1.1983 (0.7699–1.8651) | ||
| AUCtau,ss (h∙ng/mL) | 330.42 | 388.63 | 1.1762 (0.7260–1.9055) | |||
Notes: *Two participants in Group 1 were excluded after the completion of period 2. One participant in Group 1 was a PM.
Abbreviations: E, 10 mg tablet of escitalopram orally once in fasting; E+A1, 10 mg tablet of escitalopram orally once daily with Gami-soyosan, one packet thrice a day for 7 d; E+A2, 10 mg tablet of escitalopram orally once daily with Banhasasim-tang, one packet thrice a day for 7 d; E+A3, 10 mg tablet of escitalopram orally once daily with Ojeok-san, one packet thrice a day for 7 d; E+A4, 10 mg tablet of escitalopram orally once daily with Bojungikgi-tang, one packet thrice a day for 7 d; GeoLSM, geometric least squares mean; GMR, geometric least squares mean ratio; CI, confidence interval; Cmax,ss, maximum plasma concentration at steady state; AUCtau,ss, area under the plasma drug concentration–time curve over a dosing interval at steady state.