Table 2.

Cerebral blood flow in patients with AD.

Year	Patients (n)	Controls (n)	Methodologies	Phenotype	Reference
1988	36	12	133Xe inhalation	CBF reduced in AD group	144
1988	16	16	SPECT	CBF in frontal and posterior temporo-parietal cortex in AD group	145
2000	18	11	ASL-MRI	CBF reduced in temporal, parietal, frontal, and posterior cingulate cortex in AD group	151
2002	59	12	SPECT	CBF reduced in temporal, parietal, frontal cortex and hippocampus in AD group	146
2005	20	23	ASL-MRI	CBF reduced in parietal, frontal, and posterior cingulate cortex in AD group	157
2006	10	-	ASL-MRI	CBF reduced in parietal and temporal cortex, precuneus and cingulate gyrus in AD group	155
2006	-	-	Transcranial Doppler	CBF velocity reduced in the posterior cerebral artery in AD group	196
2008	12	20	ASL-MRI	CBF reduced in cingulate, temporal, parahippocampal, and fusiform gyri, thalamus, insula, and hippocampus in AD group	150
2009	19	22	ASL-MRI	Brain perfusion was reduced in the AD group	158
2009	37	38	ASL-MRI	CBF reduced in parietal, frontal, temporal, and orbitofrontal cortex in AD group	149
2013	71	73	ASL-MRI	CBF reduced in precuneus and parietal cortex in AD group	152
2014	17	37	ASL-MRI	CBF lower in cingulate gyrus, precuneus, and occipital region in AD group	154
2014	182	51	ASL-MRI	CBF reduced in throughout the brain in AD patients	148
2016	107	104	ASL-MRI	CBF reduced in advanced AD	153
2017	74	62	Phase-contrast MRI	Whole-brain perfusion was significantly lower in the AD group	159
2017	97	4636	Phase-contrast MRI	CBF associated with dementia risk	160
2021	5861	4548	Meta-Analysis	CBF reduced in AD	147
2021	156	-	ASL-MRI	Reduced CBF is associated with elevated tau in the entorhinal cortex in AD	156

SPECT : Single-Photon Emission Computed Tomography; ASL-MRI: Arterial Spin Labeled Magnetic Resonance Imaging.