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. 2024 Mar 1;19(3):e0299379. doi: 10.1371/journal.pone.0299379

Fig 2. Locomotor stimulation and sensitization after treatment with ketamine enantiomers and racemic ketamine.

Fig 2

Distance moved in 1 hour after treatment (y-axis): comparison of different treatment groups to control (x-axis) during LOC1 (left) and LOC2 (right). * indicates a statistically significant difference, p < 0.05. Diamond shape—significant increase in distance moved during LOC2 compared to LOC1 (locomotor sensitization), p < 0.05. R5–5 mg/kg of R-ketamine; S5–5 mg/kg of S-ketamine; RS15–15 mg/kg of racemic ketamine; R15–15 mg/kg of R-ketamine; S15–15 mg/kg of S-ketamine; RS30–30 mg/kg of racemic ketamine; Sal—saline.