Table 3.
MMP expression in the inflamed human intestine [compared to control]
| Gene | Protein | Activity | |
|---|---|---|---|
| Collagenases | |||
| MMP-1 | ↑ mucosa57, epithelial cells32, fibroblasts41 | ↑ mucosa57, ↔31 | ↑58 |
| MMP-8 | ↔ epithelial cells32 | ↔31, ↑59 | |
| MMP-13 | ↑60 | ||
| Gelatinases | |||
| MMP-2 | ↑ mucosa34,57,61,62, ↔ epithelial cells32 |
↑ mucosa58,34,57 | ↑ mucosa28,58,29,34 |
| MMP-9 | ↑ mucosa34,61,62, ↑ epithelial cells32 | ↑ mostly mucosa and submucosa28,58,31, mucosa29,34 | ↑ mucosa58,29 |
| Stromelysins | |||
| MMP-3 | ↑ mucosa38,57,61,62, epithelial cells32, fibroblasts41 | ↑ mucosa63,64,28,57 | ↑58 |
| MMP-10 | ↑ mucosa61,62, ↑ epithelial cells32 |
||
| Matrilysins | |||
| MMP-7 | ↑ mucosa61,62, ↑ epithelial cells32,41 |
||
| Macrophage elastase | |||
| MMP-12 | ↔ epithelial cells32, ↑ mucosa35,38,62 |
↑ mucosa64 | |
| Membrane-bound MMPs | |||
| MMP-14 | ↑ mucosa57 | ||
| Others | |||
| MMP-19 | ↔ whole intersection33, ↑ mucosa61,62 |
↔, ↓, ↑ epithelial cells [all MMP-19 forms, pro-MMP-19 peptide, hinge-region MMP-19 respectively]33 | |
| MMP-28 | ↓ mucosa62 | ||
| TIMPs | |||
| TIMP-1 | ↑ mucosa57,62, ↑ absorptive and secretory epithelial cells41 |
↔ mucosa28,64, ↑ mucosa58,63 |
|
| TIMP-2 | ↔ mucosa57, ↑ immature enterocytes and mast cells41, ↑ mucosa62 |
↔58 | |
| TIMP-3 | ↑35 | ||
↑ = increased expression or activity in tissue from IBD patients compared to controls.
↓ = decreased expression or activity in tissue from IBD patients compared to controls.
↔ = similar expression or activity in tissue from IBD patients compared to controls.