Table 4.
Expression and activity of MMPs and TIMPs in CD tissue compared to UC tissue
| Gene | Protein | Activity | |
|---|---|---|---|
| Collagenases | |||
| MMP-1 | ↔57, ↓70 | ↓58 | |
| MMP-13 | ↑35 | ↓60 | |
| Gelatinases | ↓71 | ||
| MMP-2 | ↓57 | ↓34 | ↔34, ↑72 |
| MMP-9 | ↓70 | ↔34 | ↓34,72 |
| Stromelysins | |||
| MMP-3 | ↓57,58 | ↔63 | |
| MMP-10 | ↔35 | ||
| Macrophage elastase | |||
| MMP-12 | ↔35, ↓70 | ||
| Membrane-bound MMPs | |||
| MMP-14 | ↔57 | ||
| TIMPs | |||
| TIMP-1 | ↔57 | ↔63 | |
| TIMP-2 | ↔57 | ↔58 | |
↑ = increased expression or activity in tissue from CD patients compared to UC tissue.
↓ = decreased expression or activity in tissue from CD patients compared to UC tissue.
↔ = similar expression or activity in tissue from CD patients compared to UC tissue.