Table 6.
Expression and activity of MMPs and TIMPs in fibrotic intestine compared to non-fibrotic control tissue
| Gene | Protein | Activity | |
|---|---|---|---|
| Collagenases | |||
| MMP-1 | ↑30 ↑51 |
↑ submucosa and muscularis30, ↑ muscularis and mucosa55, ↔ mucosa30, inflamed fibrotic mucosa58, ↔31 |
↔ inflamed fibrotic mucosa58 |
| MMP-8 | ↔31 | ||
| Gelatinases | |||
| MMP-2 | ↔ inflamed fibrotic mucosa58 | ↑ mucosa55, ↔ inflamed fibrotic mucosa58, ↔ muscularis55 |
|
| MMP-9 | ↔30 | ↑ mostly mucosa and submucosa31, ↔ inflamed fibrotic mucosa58 |
↔muscle and mucosa [increased compared to cancer control]55, ↔ inflamed fibrotic mucosa58 |
| Stromelysins | |||
| MMP-3 | ↑ 28, 54 | ↑ mucosa [less pronounced], submucosa and muscularis30 ↔ inflamed fibrotic mucosa58 |
↔ inflamed fibrotic mucosa58 |
| Membrane-bound MMP | |||
| MMP-14 | ↑51 | ||
| TIMPs | |||
| TIMP-1 | ↔,30 ↑51 |
↑ muscle55, ↔ mucosa55, ↔inflamed fibrotic mucosa58 |
|
| TIMP-2 | ↔ inflamed fibrotic mucosa58 | ||
↑ = increased expression or activity in fibrotic tissue from CD patients compared to control tissue.
↓ = decreased expression or activity in fibrotic tissue from CD patients compared to control tissue.
↔ = similar expression or activity in fibrotic tissue from CD patients compared to control tissue.