Table 7.
In vitro MMP and TIMP expression
| Fibroblast source | Comparison | mRNA | Protein | Activity |
|---|---|---|---|---|
| Stenotic | Stenotic vs non-stenotic fibroblasts | ↔ MMP-1, -16, and -1753; ↓ MMP-3, -10, -11, and -2453; ↑ MMP-2 and TIMP-253; ↑ TIMP-166,88 |
↓ MMP-1266,84; ↔ MMP-366,84; ↑ TIMP-166,88; ↔ TIMP-184; ↔ TIMP-288 |
↓ MMP-1266 ↑ MMP-2 and -353 |
| Normal | Plastic vs matrix cultured fibroblasts | ↑ MMP-389 | ↑ MMP-2 | |
| Ccd-18Co | Plastic vs matrix cultured fibroblasts | ↑ MMP-3 | ↑ MMP-271 | |
| Normal | Increasing stiffness | ↑ MMP-353 | ||
| Stenotic | Increasing stiffness | ↓ MMP-353 | ||
| Ccd-18Co | Increasing stiffness | ↓ MMP-1 and -356 | ↓ MMP-353 |
↑ = increased expression or activity.
↓ = decreased expression or activity.
↔ = similar expression or activity.