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Role of TGF-β in vitro expression of MMPs and TIMPs
| In vivo | In vitro | |||
|---|---|---|---|---|
| Pro/anti-fibrotic | Expression in intestinal fibrosisa | mRNAb | Proteinb | |
| TGF-β1 | Pro-fibrotic | ↑ | MMP-1 ↔; TIMP-1 ↑ | MMP-2 and TIMP-1 ↑; MMP-3 ↔; MMP-9 ↑; MMP-12 ↓ |
| TGF-β2 | ↑ | TIMP-1 ↑ | ||
| TGF-β3 | Anti-fibrotic | ↓ | TIMP-1 ↔ | |
↑ = increased expression compared to control.
↓ = decreased expression compared to control.
↔ = similar expression compared to control.
aCompared to non-fibrotic control.
bCompared to non-treated control.
