Table 2.
Resting hemodynamic variables in YF, YM, and PMF
YF | YM | PMF | Test Statistic | P Value | |
---|---|---|---|---|---|
MSNA, bursts/100 HB | 53 [13]* | 51 [11]* | 79 [17] | χ2(2) = 20.131 | <0.0005 |
MSNA, bursts/min | 33 [10]* | 29 [6]* | 52 [13] | χ2(2) = 21.090 | <0.0005 |
MSNA, total area/s, % | 8.6 [3.4]* | 8.4 [1.6]* | 10.9 [3.3] | χ2(2) = 14.922 | 0.0006 |
Heart rate, beats/min | 62 ± 10 | 58 ± 9 | 64 ± 7 | F(2, 34) = 1.458 | 0.247 |
SBP, mmHg | 136 [17] | 125 [8]* | 146 [21] | χ2(2) = 10.866 | 0.004 |
DBP, mmHg | 78 [13] | 69 [9] | 72 [13] | χ2(2) = 1.945 | 0.378 |
PP, mmHg | 59 ± 7† | 52 ± 5* | 71 ± 16 | F(2,21.1) = 10.545 | 0.001 |
MAP, mmHg | 98 [12] | 88 [8] | 97 [14] | χ2(2) = 5.474 | 0.065 |
sBRS occurrence, % bursts/mmHg | −5.3 [1.6] | −7.1 [4.3]* | −3.4 [3.7] | χ2(2) = 8.423 | 0.015 |
sBRS area, %/mmHg | −0.51 ± 0.29 | −0.62 ± 0.28 | −0.56 ± 0.25 | F(2, 34) = 0.456 | 0.638 |
Breathing rate, breaths/min | 14 [2] | 13 [6] | 13 [5] | χ2(2) = 0.401 | 0.818 |
Normalized respiratory trace amplitude, % | 46 ± 15 | 55 ± 17 | 50 ± 19 | F(2, 34) = 0.829 | 0.445 |
Respiratory cycle duration, s | 4.1 [0.6] | 4.5 [2.1] | 4.6 [1.7] | χ2(2) = 0.707 | 0.702 |
Values are represented as means ± SD or medians [interquartile ranges]. YF, premenopausal females; HB, heartbeats; sBRS, sympathetic baroreflex sensitivity; χ, Kruskal–Wallis test statistic; F, ANOVA test statistic. Group differences tested by univariate ANOVA or Kruskal–Wallis test. Welch’s correction was applied to pulse pressure (PP) data.
P < 0.05 vs. postmenopausal females (PMF); †P < 0.05 vs. younger males (YM) (exact P values in text). Multiple comparisons for muscle sympathetic nerve activity (MSNA), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), breathing rate compared mean ranks.