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Cardiac damage in dystrophic hearts following sustained preload challenge. Summary data of coronary lactate dehydrogenase (LDH) in wild-type (WT, circles) and Dmdmdx-4Cv (squares) hearts at 0-mmHg (A) and 30 min following 20-mmHg preload challenge (B). Data include hearts with (green symbols) and without (open symbols) cardiomyocyte GCaMP6f expression. ***P = 0.0007; WT vs. Dmdmdx-4Cv, one-tailed Mann–Whitney U test. n = 6, 3–6-mo WT and n = 8, 3–6-mo Dmdmdx-4Cv hearts.
