Table 2.
Associations between changes over time in mean diffusivity and changes over time in cognitive performance
| Standardized-β | Standard error | t-value | P-value | 95% Confidence intervals | |
|---|---|---|---|---|---|
| Early-Aβ ROI | |||||
| mPACC | −0.49 | 0.05 | −10.19 | <0.001 | −0.59 to −0.40 |
| TMT-B | 0.49 | 0.08 | 6.44 | <0.001 | 0.34 to 0.64 |
| ADAS delayed recall | 0.46 | 0.05 | 10.20 | <0.001 | 0.37 to 0.55 |
| Temporal ROI | |||||
| mPACC | −0.60 | 0.04 | −13.61 | <0.001 | −0.69 to −0.52 |
| TMT-B | 0.61 | 0.08 | 7.98 | <0.001 | 0.45 to 0.76 |
| ADAS delayed recall | 0.57 | 0.04 | 13.66 | <0.001 | 0.49 to 0.65 |
Aβ = amyloid-β; ADAS = Alzheimer’s Disease Assessment Scale; mPACC = modified version of the Preclinical Alzheimer Cognitive Composite; ROI = region of interest; TMT-B = Trail Making Test Part B.