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. 2023 Sep 6;147(3):858–870. doi: 10.1093/brain/awad297

Figure 3.

Figure 3

Spatiotemporal gene expression of all mapped genes to shared loci between Parkinson’s disease and age at menarche. The dendrogram and heat map were built using RNA sequencing data from BrainSpan over 11 developmental periods (columns) and 16 brain regions (rows). Gene expression was measured as log2 transformed RPKM (reads per kilobase per million mapped reads). Global expression of mapped genes to shared loci between Parkinson’s disease and age at menarche had the highest expression during late childhood, most prominent in neocortical areas. Gene expression varied from a minimum of 2.6 log2(RPKM) and to a maximum of 5.1 log2(RPKM).