| Doxycycline |
100 mg daily starting 2 days prior to entering the endemic area, continued four weeks after return |
Do not take along with milk or other dairy or calcium-rich meals; ensure adequate fluid intake and protection against sunburn |
| Contraindications: pregnancy and lactation; children <8 years |
| Side effects: photosensitivity; gastrointestinal (GIT) disturbances |
|
| Atovaquone/proguanil |
One tablet (250/100 mg adult) daily starting 2 days prior to entering the endemic area, continued one week after return |
Take with milk or fatty foods; repeat dose if vomiting within 1 hour of dosing; caution advised in patients with a history of epilepsy or active treatment with anticoagulants |
| Contraindications: children <11 kg; renal impairment |
| Side effects: initial gastric intolerance; treatment should be discontinued in the case of a severe rash or mucosal involvement |
|
| Mefloquine |
One tablet (250 mg) weekly (every 7 days) starting 10 days prior to entering the endemic area, continued four weeks after return |
Take after meals with adequate fluid; drug of choice in pregnancy and lactation; avoid activities requiring fine motor coordination |
| Contraindications: psychiatric disorders, epilepsy, infants <5 kg; cardiac conduction abnormalities; hepatic impairment |
| Side effects: headache, dizziness, vertigo, mood changes, and sleep disturbances; GIT and visual disturbances |
