Table 3.
Hazard Ratios for Baseline Characteristics and the Outcome of Relapse
| Variable | Value | Unadjusted | |||
|---|---|---|---|---|---|
| Hazard Ratio | 95% CI | P-value | |||
| Age, per year | 0.99 | 0.96 | 1.02 | 0.48 | |
| Sex | |||||
| Female | 0.73 | 0.36 | 1.49 | 0.39 | |
| Male | 1.00 | (referent) | |||
| R-ISS | |||||
| I or II | 1.00 | (referent) | |||
| III | 2.20 | 0.88 | 5.45 | 0.09 | |
| Ionized calcium | |||||
| Normal (<=1.29) | 1.00 | (referent) | |||
| Elevated (>1.29) | 2.76 | 1.28 | 5.97 | 0.0099 | |
| Glomerular filtration rate | |||||
| ≥60 | 1.00 | (referent) | |||
| <60 | 1.62 | 0.78 | 3.33 | 0.19 | |
| Pathologic fracture | |||||
| No | 1.00 | (referent) | |||
| Yes | 1.50 | 0.74 | 3.06 | 0.26 | |
| Hemoglobin | |||||
| <100 | 1.37 | 0.66 | 2.82 | 0.40 | |
| ≥100 | 1.00 | (referent) | |||
| Best response | |||||
| Complete or very good partial response | 1.00 | (referent) | 0.90 | ||
| Partial response or stable disease | 0.94 | 0.42 | 2.13 | ||
| Progressive disease | 1.72 | 0.40 | 7.39 | ||
| Autologous stem cell transplant | |||||
| No | 1.00 | (referent) | |||
| Yes | 0.71 | 0.34 | 1.46 | 0.35 | |
| Maintenance therapy | |||||
| No | 1.00 | (referent) | |||
| Yes | 0.80 | 0.38 | 1.66 | 0.54 | |