Fig. 1.

Overview of the study design. EPIC, European Prospective Investigation into Cancer and Nutrition; IARC, International Agency for Research on Cancer; Serum fatty acid data (expressed as a percentage of total fatty acids)—industrial trans fatty acid, monounsaturated fatty acid, natural trans fatty acid, polyunsaturated fatty acid; Dietary intake data (g/day)—mono-unsaturated fatty acid, polyunsaturated fatty acid, saturated fatty acid, total cholesterol, fat, animal fat, carbohydrate, starch, sugar, protein, animal protein, red and processed meat, dairy, fibre; Lifestyle data—alcohol consumption at recruitment (g/day), Cambridge physical activity index (inactive, moderately inactive, moderately active, active), smoking status (never, former, current), body mass index (kg/m²), height (cm), waist circumference (cm), waist-to-hip ratio; Biomarker data—cholesterol (mmol/l), low-density lipoprotein (LDL) cholesterol (mmol/l), high-density lipoprotein (HDL) cholesterol (mmol/l), triglycerides (mmol/l), C-peptide [ng/ml], C-reactive protein [ng/ml], insulin-like growth factor-1 (IGF-1) [nmol/l]).