Fig. 6. ChAd vaccines protect Syrian hamsters against XBB.1.5 infection.
a, Experimental design. b, Anti-Wuhan-1 and anti-BA.5 S protein responses in the sera of hamsters immunized i.n. with monovalent ChAd-SARS-CoV-2-S (blue) or bivalent ChAd vaccine (green). Animals immunized with PBS were used as controls (black). Serum was collected 21 d after immunization. c, Serum neutralizing antibody responses against WA1/2020 D614G, BA.5 and XBB1.5. d, Weight loss/gain (percent of initial weight) (mean ± s.e.m.) of hamsters challenged with SARS-CoV-2. e–g, Infectious virus titers and viral RNA levels determined 3 d after XBB.1.5 challenge in nasal turbinates (e), nasal washes (f) and lungs (g). Bars indicate the geometric mean values, and dotted lines denote the LOD of the assays (two experiments, n = 9 for all assessments). Data in b, c and e–g were analyzed by one-way ANOVA with a Tukey’s post hoc test; *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001.