Table 1.

Tobramycin and polymyxin B MICs at baseline and after 48 h of antibiotic treatment in air-liquid interface PK/PD biofilm model and planktonic one-compartment model

Bacterial Isolate	Tobramycin MICs, mg/L
	Treatment Condition	Baseline MIC (0 h)	Post-Exposure MIC (48 h)
			Biofilm	Planktonic
PAO1	Growth Control	0.5	1	1
	Tobramycin IV		1	1
	Tobramycin INH		0.5	1
AR0064	Growth Control	4	4	4
	Tobramycin IV		4	4
	Tobramycin INH		8	8

	Polymyxin B MICs, mg/L
	Treatment Condition	Baseline MIC (0 h)	Post-Exposure MIC (48 h)
			Biofilm	Planktonic
PAO1	Growth Control	1	2	1
	Polymyxin B IV		1	2
	Polymyxin B INH		1	1
AR0064	Growth Control	1	1	1
	Polymyxin B IV		2	2
	Polymyxin B INH		2	2