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. 2024 Mar 1;24(1):47. doi: 10.1007/s10238-024-01307-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Composition of the CD4⁺ T cell pool with ICOS⁺ and ICOS⁻ Tregs/Tresps and ratio of ICOS⁺/ICOS⁻ Tregs/Tresps in women and men. The percentages of ICOS⁺ Tregs/Tresps within total CD4⁺ T cells in women (A and C) and men (B and D) as well as of ICOS⁻ Tregs/Tresps in women (G and I) and men (H and J) were estimated depending on age in healthy volunteers () and SLE patients in remission (). The ratios of ICOS⁺ Tregs/Tresps or ICOS⁻ Tregs/Tresps are shown in women (E and K) and men (F and L). Significant age-dependent changes are marked by black or green p-values. Significant age-independently increased or decreased percentages/ratios in SLE patients in remission compared to healthy volunteers are marked by an arrow (↑↓) and green underlined p values

Inline graphic — Composition of the CD4⁺ T cell pool with ICOS⁺ and ICOS⁻ Tregs/Tresps and ratio of ICOS⁺/ICOS⁻ Tregs/Tresps in women and men. The percentages of ICOS⁺ Tregs/Tresps within total CD4⁺ T cells in women (A and C) and men (B and D) as well as of ICOS⁻ Tregs/Tresps in women (G and I) and men (H and J) were estimated depending on age in healthy volunteers () and SLE patients in remission (). The ratios of ICOS⁺ Tregs/Tresps or ICOS⁻ Tregs/Tresps are shown in women (E and K) and men (F and L). Significant age-dependent changes are marked by black or green p-values. Significant age-independently increased or decreased percentages/ratios in SLE patients in remission compared to healthy volunteers are marked by an arrow (↑↓) and green underlined p values