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. 2024 Mar 1;24(1):47. doi: 10.1007/s10238-024-01307-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Differentiation pathways of ICOS⁺ RTE Tresps into CD31⁻ memory Tresps and percentages of Ki67⁺ cells within ICOS⁺ Tresp subsets in women and men. Three possible differentiation pathways, via CD31⁺ memory Tresps (pathway 1), via direct proliferation (pathway 2), or via differentiation of resting MN Tresps (pathway 3) are shown in (A). The percentages of Ki67⁺ cells within ICOS⁺ RTE, MN, CD31⁺ memory and CD31⁻ memory Tresps in women (B) and men (C) were estimated depending on age in healthy volunteers () and SLE patients in remission (). Significant age-dependent changes are marked by black or green p-values. Significant age-independently increased or decreased percentages in SLE patients in remission compared to healthy volunteers are marked by an arrow (↑↓) and green underlined p-values

Inline graphic — Differentiation pathways of ICOS⁺ RTE Tresps into CD31⁻ memory Tresps and percentages of Ki67⁺ cells within ICOS⁺ Tresp subsets in women and men. Three possible differentiation pathways, via CD31⁺ memory Tresps (pathway 1), via direct proliferation (pathway 2), or via differentiation of resting MN Tresps (pathway 3) are shown in (A). The percentages of Ki67⁺ cells within ICOS⁺ RTE, MN, CD31⁺ memory and CD31⁻ memory Tresps in women (B) and men (C) were estimated depending on age in healthy volunteers () and SLE patients in remission (). Significant age-dependent changes are marked by black or green p-values. Significant age-independently increased or decreased percentages in SLE patients in remission compared to healthy volunteers are marked by an arrow (↑↓) and green underlined p-values