Fig. 1. Changes in MV-PVS metrics from pre- to post-bed rest for persons with signs of SANS compared to those without.

The HDBR + CO₂ data are split into SANS (green) and No-SANS (purple) subgroups. Bars represent standard deviation. The width of the blue box indicates the duration of HDBR + CO₂. *Indicates a statistically significant (p < 0.05) group difference between the SANS and No-SANS participants for changes in median MV-PVS volume and diffusivity along the PVS with bed rest. ^†Indicates a statistical trending (p < 0.10) change in median MV-PVS width and median MV-PVS volume from pre- to post-bed rest. Significant changes in recovery were examined in instances where significant pre- to post-bed rest changes occurred (i.e., median MV-PVS volume). SANS spaceflight-associated neuro-ocular syndrome, MV-PVS magnetic resonance imaging-visible perivascular space, WM white matter.