Table 1.

Therapeutic effects of functional inhibitors targeting ASM in neurological pathologies.

Name	Target tissue or cell	Disease	Mouse model	Therapeutic effects	Ref
Amitriptyline	Brain	Major depression	ASM-transgenic mice Stress-induced mice	Hippocampal neuronal loss ↓ Hippocampal neurogenesis ↑ Behavioral dysfunction ↓	44,92
	Brain	Ischemic stroke	Focal cerebral ischemia-induced mice	Leukocyte brain infiltration ↓ Angiogenesis ↑ Neuronal survival ↑	93
	Brain Blood	Alzheimer’s disease	APP/PS1	Aβ accumulation ↓ Abnormal neuronal autophagy ↓ Memory impairment ↓	25,43
	BBB-ECs Blood	Aging	20-month-old WT mice	BBB disruption ↓ Neuronal loss ↓ Memory impairment ↓	24
Fluoxetine	Brain	Major depression	ASM-transgenic mice Stress-induced mice	Hippocampal neuronal loss ↓ Hippocampal neurogenesis ↑ Behavioral dysfunction ↓	44,92
	Brain	Ischemic stroke	Focal cerebral ischemia-induced mice	Angiogenesis ↑ Motor-coordination recovery ↑	93
Imipramine	Brain	Traumatic brain injury	TBI-induced rat	Hippocampal neuronal death ↓ Neuroinflammation ↓ Cognitive dysfunction ↓	94