Table 2.

Therapeutic effects of direct inhibitors targeting ASM in neurological pathologies.

Name	Target tissue or cell	Disease	Mouse model	Therapeutic effect	Ref
ARC 39 AD 2765 ent-12	Not proven
KARI 201	Neurons Blood	Alzheimer’s disease	APP/PS1 5xFAD	Aβ accumulation ↓ Abnormal neuronal autophagy ↓ Neuroinflammation ↓ Synaptic loss ↓ Hippocampal neurogenesis ↑ Synaptic plasticity ↑ Memory impairment ↓	43
23A12C3	CD4+ T cells Blood	Alzheimer’s disease	APP/PS1	Pathogenic Th17 cells ↓ Aβ accumulation ↓ Neuroinflammation ↓ Memory impairment ↓	26