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. 2024 Mar 1;15:1916. doi: 10.1038/s41467-024-46088-z

Fig. 5. Bright-field microscopy reveals acute constriction of CPu microvessels to Enk analog in mouse brain slices.

Fig. 5

a Average microvessel diameter during 5 min experimental epochs (in order: aCSF (baseline), TXA2 + aCSF (pretreatment), DADLE + TXA2 + aCSF (Enk analog), TXA2 + aCSF (washout)) for 8 CPu microvessels (n = 3 mice). Šídák’s multiple comparisons test versus preceding experimental condition; *adjusted p < 0.05, ****adjusted p < 0.0001. b Representative microvessel showing constriction of vessel diameter (indicated by yellow arrows) to DADLE (purple frame) versus TXA2 pretreatment and washout (left and right blue frames, respectively). Box plots span IQR, with median line and whiskers within bounds ±1.5 IQR, using Tukey’s method. Exact p-values and test statistics are in Source Data. Source data are provided as a Source Data file.