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Schematic diagram of immune checkpoint inhibitors blocking T cell activation. Abbreviations: APC, antigen-presenting cell; CTLA-4, cytotoxic T lymphocyte antigen-4; ICI, immune checkpoint inhibitor; MHC, major histocompatibility complex; PD-1, programmed death-1; PD-L1, programmed death ligand-1; TCR, T cell receptor; LAG-3, lymphocyte activation gene-3. Figure created with BioRender.com.
