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. 2024 Feb 8;43(5):836–867. doi: 10.1038/s44318-024-00034-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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The hop1-loop2 allele is simplified to loop2 in figure labels. (A) Meta-analysis of Hop1 ChIP-seq associated with axis positions in either centromere (defined as any axis site within 20 kb +/− the centromere) or axis positions outside of defined centromere regions. Solid line represents average of axis binding, and shaded region corresponds to 95% confidence intervals. Nonoverlapping confidence intervals are considered to be statistically significant. (B) Hop1 ChIP-seq flanking centromere regions for each chromosome. (C) Same as panel B but for Rec8 ChIP-seq data available for wild type (Sun et al, 2015).