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. 2024 Feb 8;43(5):836–867. doi: 10.1038/s44318-024-00034-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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(A) CC-sequencing (magenta), with two replicates, is plotted along chromosome XIII as hits per million (HpM) for rad50S and rad50S hop1-loop2 cultures collected at 6 h. Hop1 ChIP signal (blue) is also plotted to compare the relative positions of Hop1 binding and DSB activity. The dotted lines indicate the zoom region plotted to the right of the whole chromosome plot. Black bars represent island regions, black triangles represent centromeres. (B) Meta-analysis of CC-sequencing data comparing read counts associated with hotspots in axis island regions with read counts associated with hotspots in non-axis regions for either rad50S cells or rad50S hop1-loop2 cells. Shaded regions outside of the averages represent 95% confidence intervals. (C) Ratio plots for the average number of DSBs per chromosome in hop1-loop2 rad50S compared to the average number of DSBs per chromosome in rad50S cultures. The chromosomes are organized from smallest to largest. (D) Similar plots as (B), except comparing CC-sequencing data associated in hotspots 20 kb +/− the centromere to CC-sequencing data associated with hotspots outside these regions.