Table 3.
Baseline predictors of unacceptable pain and unacceptable pain with low inflammation at follow-ups.
| Unacceptable pain |
Unacceptable pain with low inflammation |
|||
|---|---|---|---|---|
| 1 year | 2 years | 1 year | 2 years | |
| Variable | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) |
| Female | 2.59 (1.09, 6.13) | 0.90 (0.38, 2.12) | 3.72 (1.22, 11.34) | 1.13 (0.44, 2.87) |
| RF positive | 1.31 (0.60, 2.87) | 0.67 (0.28, 1.59) | 0.82 (0.36, 1.87) | 0.63 (0.25, 1.55) |
| Anti-CCP positive | 0.59 (0.29, 1.22) | 0.74 (0.32, 1.73) | 0.67 (0.30, 1.50) | 0.69 (0.28, 1.69) |
| Age | 1.07 (0.72, 1.60) | 1.11 (0.73, 1.68) | 1.26 (0.79, 2.01) | 0.90 (0.58, 1.39) |
| Symptom duration | 1.04 (0.73, 1.50) | 0.92 (0.60, 1.39) | 1.07 (0.72, 1.60) | 1.02 (0.66, 1.60) |
| VAS pain | 1.35 (0.91, 2.02) | 1.23 (0.76, 2.04) | 1.40 (0.90, 2.17) | 1.19 (0.70, 2.03) |
| SJC28 | 0.96 (0.67, 1.40) | 0.94 (0.65, 1.36) | 0.90 (0.60, 1.35) | 0.99 (0.67, 1.46) |
| TJC28 | 1.07 (0.76, 1.49) | 1.20 (0.83, 1.73) | 0.96 (0.66, 1.41) | 1.25 (0.85, 1.84) |
| HAQ | 1.58 (1.08, 2.30) | 1.33 (0.86, 2.07) | 1.50 (1.00, 2.25) | 1.14 (0.72, 1.82) |
| CRP | 0.99 (0.72, 1.35) | 0.72 (0.44, 1.17) | 0.72 (0.43, 1.19) | 0.61 (0.33, 1.15) |
| ESR | 1.01 (0.94, 1.46) | 0.88 (0.59, 1.30) | 0.83 (0.53, 1.30) | 0.77 (0.49, 1.21) |
| VAS PGA | 1.26 (0.83, 1.92) | 1.49 (0.91, 2.42) | 1.38 (0.87, 2.20) | 1.18 (0.71, 1.98) |
| Fatigue | 1.34 (0.83, 2.17) | 1.99 (1.03, 3.84) | 1.56 (0.93, 2.63) | 1.70 (0.84, 3.45) |
| DAS28-CRP | 1.08 (0.72, 1.63) | 1.07 (0.65, 1.74) | 1.05 (0.67, 1.65) | 1.03 (0.61, 1.74) |
| Tender-swollen difference | 1.16 (0.82, 1.64) | 1.29 (0.93, 1.79) | 1.07 (0.73, 1.57) | 1.29 (0.91, 1.81) |
| Tender-dominateda | 1.11 (0.52, 2.40) | 1.35 (0.59, 3.13) | 1.34 (0.58, 3.09) | 1.45 (0.60, 3.49) |
Univariate logistic regression analysis. Odds ratios are calculated per standard deviation for continuous variables. Values in bold indicate statistical significance with P-values <0.05. Unacceptable pain: VAS pain >40. Low inflammation: CRP <10.
DAS28-CRP: disease activity score in 28 joints calculated with CRP; OR: odds ratio; PGA: patient global assessment; SJC28: swollen joint count in 28 joints; TJC28: tender joint count in 28 joints; VAS: visual analogue scale.
a
TJC28 > SJC28 × 1.5.