Table 4.

Three-month predictors of unacceptable pain and unacceptable pain with low inflammation at follow-ups.

	Unacceptable pain		Unacceptable pain with low inflammation
	1 year	2 years	1 year	2 years
Variable	OR (95% CI)	OR (95% CI)	OR (95% CI)	OR (95% CI)
VAS pain	2.08 (1.32, 3.27)	2.73 (1.61, 4.60)	2.28 (1.39, 3.74)	2.84 (1.65, 4.87)
SJC28	1.26 (0.89, 1.78)	1.19 (0.77, 1.83)	1.35 (0.95, 1.92)	1.25 (0.80, 1.93)
TJC28	1.68 (1.12, 2.52)	1.73 (1.07, 2.81)	1.75 (1.16, 2.64)	1.81 (1.11, 2.97)
HAQ	2.61 (1.63, 4.18)	2.36 (1.45, 3.83)	2.59 (1.57, 4.25)	2.12 (1.32, 3.40)
CRP	1.27 (0.88, 1.84)	1.27 (0.88, 1.84)	1.12 (0.78, 1.62)	1.27 (0.88, 1.84)
ESR	1.52 (0.95, 2.45)	1.30 (0.80, 2.12)	1.19 (0.74, 1.91)	1.29 (0.78, 2.13)
VAS PGA	2.25 (1.43, 3.56)	3.32 (1.87, 5.88)	2.69 (1.59, 4.54)	3.05 (1.73, 5.38)
DAS28-CRP	2.05 (1.34, 3.14)	2.17 (1.33, 3.55)	2.16 (1.36, 3.44)	2.15 (1.31, 3.54)
Low disease activitya	0.25 (0.10, 0.59)	0.17 (0.06, 0.48)	0.19 (0.07, 0.55)	0.20 (0.07, 0.60)
Tender-swollen difference	1.47 (0.97, 2.22)	2.00 (1.14, 3.52)	1.46 (0.97, 2.19)	2.02 (1.15, 3.58)
Tender-dominatedb	2.15 (0.97, 4.81)	1.87 (0.75, 4.69)	3.01 (1.24, 7.34)	2.05 (0.79, 5.32)

Univariate logistic regression analysis. Odds ratios are calculated per standard deviation for continuous variables. Bold text indicates statistical significance with P-values <0.05. Italic text indicates P-values ≥0.05 and <0.10. Bold plus italic text indicates P-values <0.001. Unacceptable pain: VAS pain >40. Low inflammation: CRP <10.

DAS28-CRP: disease activity score in 28 joints calculated with CRP; OR: odds ratio; PGA: patient global assessment; SJC28: swollen joint count in 28 joints; TJC28: tender joint count in 28 joints; VAS: visual analogue scale.

^aDAS28-CRP ≤3.2.

^bTJC28 > SJC28 × 1.5.