1. Anti‐fungal agents studied in the included trials.

Study	Intervention	Dose	Treatment duration	Intervention	Dose	Treatment duration
Agarwal 2001	Topical itraconazole	1% every hour	For 6 weeks after keratitis resolved	Oral itraconazole Topical itraconazole	100 mg twice daily 1% every hour	3 weeks For 6 weeks after keratitis resolved
Arora 2011	Topical natamycin	5% every hour	Two weeks "Further dosage titrated according to the patient's response"	Topical voriconazole	1% every hour	Two weeks "Further dosage titrated according to the patient's response"
Basak 2004	Intracameral amphotericin B combined with conventional medication as given to control group	5 to 15 μg	Depending upon the size of the ulcer and amount of hypopyon the injection was repeated after 7 days as indicated Complications were treated medically, surgically, or both	Conventional medication: (1) oral fluconazole (2) topical natamycin (3) topical amphotericin B (4) broad‐spectrum topical antibiotic (5) topical antiglaucoma medication (6) topical cycloplegics	(1) 150 to 200 mg (2) 5% every hour (3) 0.15% every hour (4) every 2 hours	(1) twice a day for 3 weeks
Mahdy 2010	Topical amphotericin B Subconjunctival injection of fluconazole	0.05% every 2 hours 0.5 mL of 2 mg/mL daily	N/A 20 injections, first 10 every day, second 10 every 2 days	Topical amphotericin B	0.05% every 2 hours	N/A
Mohan 1987	Topical silver sulphadiazine	2 doses studied: 0.5% and 1%, applied 5 times a day	N/A	Topical miconazole	1% applied 5 times a day	N/A
MUTT 2010	Topical natamycin 5%	1 drop was applied to the affected eye every hour, while awake, for 1 week, then every 2 hours while awake until 3 weeks from enrolment	3 weeks	Topical voriconazole 1%	1 drop was applied to the affected eye every hour, while awake, for 1 week, then every 2 hours while awake until 3 weeks from enrolment	3 weeks
Parchand 2012	Oral and topical voriconazole 1%	Oral voriconazole was given in tablet form 400 mg twice a day on day 1 followed by 200 mg twice a day and continued until the resolution of the infiltrates. Topical voriconazole was given every hour, while awake, for 1 week, then every 2 hours while awake until healing of the epithelial defect and then gradual tapering off.	Until healed	Oral voriconazole and topical natamycin 5%	Oral voriconazole was given in tablet form 400 mg twice a day on day 1 followed by 200 mg twice a day and continued until the resolution of the infiltrates. Topical natamycin was given every hour, while awake, for 1 week, then every 2 hours while awake until healing of the epithelial defect and then gradual tapering off.	Until healed
Prajna 2003	Topical natamycin	5% every hour between 7am and 9pm	4 weeks	Topical econazole	2% every hour between 7am and 9pm	4 weeks
Prajna 2010*	Topical natamycin	5% every hour while awake	Every hour for 1 week followed by every 2 hours for 2 weeks, further continuation at discretion of physician	Topical voriconazole	1% every hour while awake	Every hour for 1 week followed by every 2 hours for 2 weeks, further continuation at discretion of physician
Rahman 1997	Topical natamycin	5%	Day 1: Half‐hourly for 3 hours, hourly during waking hours for rest of day. Days 2 to 5: 2‐hourly, then 3‐hourly for a further 2 weeks. If no improvement at 5 days swapped to another treatment	Topical chlorhexidine gluconate	Three doses studied: 0.05%, 0.1% and 0.2%	Day 1: Half‐hourly for 3 hours, hourly during waking hours for rest of day. Days 2 to 5: 2‐hourly, then 3‐hourly for a further 2 weeks. If no improvement at 5 days swapped to another treatment
Rahman 1998	Topical natamycin	2.5%	Half‐hourly for first 3 hours, then 1‐hourly for 2 days, 2‐hourly for 5 days, and 3‐hourly for 3 weeks. If no improvement at 5 days treatment changed	Topical chlorhexidine gluconate	0.2%	Half‐hourly for first 3 hours, then 1‐hourly for 2 days, 2‐hourly for 5 days, and 3‐hourly for 3 weeks. If no improvement at 5 days treatment changed
Sharma 2013	Topical voriconazole as an adjunct to natamycin	1%	Hourly for the initial 48 hours, then were tapered to every 2 hours while awake for 72 hours and thereafter the dosage was every 4 hours. Further tapering of the drug depended on the response of the infection to treatment and as per the clinician’s judgment.	Instrastromal voriconazole as an adjunct to natamycin	0.5 mg/mL voriconazole was injected obliquely into the cornea. 5 divided doses were given around the ulcer to form a deposit of the drug around the circumference of the lesion. At least 3 injections were given 72 hours apart.	Both groups received topical 5% natamycin eye drops every 4 hours, 0.3% ciprofloxacin hydrochloride eye drops 4 times daily, and 2% homatropine eye drops 3 times daily.

* Participants were also randomised to "scraping of the corneal epithelium"