Basak 2004.

Methods	Parallel group randomised controlled trial Cases enrolled and randomly allocated, number of people/eyes not reported. Date conducted: not reported
Participants	Setting: community‐based tertiary care hospital in India Participants: 45 (31 men, 14 women), average age 33 years Inclusion criteria: deep keratomycosis with endothelial plaque; non‐mobile cheesy hypopyon of various height; all cases were smear positive for fungus on potassium hydroxide or Gram stain, or both; smear (Gram stain) was negative for bacteria in all cases. Exclusion criteria: keratomycosis without hypopyon; mixed ulcer on microscopic examination of the smear; ulcer with impending or frank perforation; after 48 hours if any bacterial culture report became positive.
Interventions	Intracameral amphotericin B 5 μg to 15 μg with conventional medication (N = 23) Conventional medication (N = 22) Conventional medication was: oral fluconazole 150 mg to 200 mg twice a day for 3 weeks; topical natamycin 5% every hour; topical amphotericin B 0.15% every hour; broad‐spectrum topical antibiotic every 2 hours; topical antiglaucoma medication; topical cycloplegics. Intracameral injection of amphotericin B was given in a dose between 5 μg and 15 μg depending upon the size of the ulcer and amount of hypopyon. Injection was repeated after 7 days as indicated. Complications were treated medically or surgically, or both.
Outcomes	Healing of deep fungal keratitis Complications (perforation, anterior staphyloma, phthisis bulbi, panophthalmitis) Follow‐up: day 1, 3, 7 and then weekly until ulcer healed.
Notes	Funding: not reported Conflict of interest: "The Authors do not have any proprietary interest in the method or subject matter mentioned in this article."
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not reported
Allocation concealment (selection bias)	Unclear risk	Not reported
Blinding of participants and personnel (performance bias) All outcomes	High risk	Not reported but interventions quite different
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not reported
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Not reported
Selective reporting (reporting bias)	Unclear risk	No access to protocol