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. 2015 Apr 9;2015(4):CD004241. doi: 10.1002/14651858.CD004241.pub4

Mohan 1987.

Methods Parallel group randomised controlled trial (after 1 week, patients who had not responded were randomly allocated to another treatment)
Eyes enrolled, unclear if 1 eye per person
Date conducted: not reported
Participants Setting: New Delhi, India
 Participants: 30, age and sex not reported
Inclusion criteria: clinical diagnosis of fungal keratitis with positive for potassium hydroxide or Grams smear, or both
Exclusion criteria: not specified
Interventions
  • Topical silver sulphadiazine 0.5% (N = 10)

  • Topical silver sulphadiazine 1% (N = 10)

  • Topical miconazole 1% (N = 10)


All three drugs were prepared in an ointment base and were applied 5 times a day. Cycloplegics (atropine or homatropine), antiglaucoma medication (acetazolamide, glycerol) and vitamins (A, B complex and C) were given where indicated.
Outcomes
  • Healing (defined as absence of fluorescein staining, disappearance of hypopyon, lack of circumcorneal congestion and negative culture)

Notes Funding: not reported
Conflict of interest: not reported
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk "The cases were divided into 3 treatment groups […] on a random basis” Page 573
Allocation concealment (selection bias) Low risk The drugs […were] coded by the Ocular Pharmacology LaboratoryPage 573
At the end of the trial, the code was broken and the result analyzed” Page 573
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk Each patient was given a coded antifungal ointment tube of 5g to be applied 5 times a day and the entire study was conducted in a double blind manner” Page 573
Blinding of outcome assessment (detection bias) 
 All outcomes Unclear risk The drugs […were] coded by the Ocular Pharmacology Laboratory” Page 573
Each patient was given a coded antifungal ointment tube of 5g to be applied 5 times a day and the entire study was conducted in a double blind manner” Page 573
At the end of the trial, the code was broken and the result analyzed” Page 573
Incomplete outcome data (attrition bias) 
 All outcomes Low risk There was no fallout from this study on account of poor patient compliance” Page 573
Selective reporting (reporting bias) Low risk Probably not a problem as they reported ulcers responding to treatment