Mohan 1987.
Methods | Parallel group randomised controlled trial (after 1 week, patients who had not responded were randomly allocated to another treatment) Eyes enrolled, unclear if 1 eye per person Date conducted: not reported |
|
Participants | Setting: New Delhi, India
Participants: 30, age and sex not reported Inclusion criteria: clinical diagnosis of fungal keratitis with positive for potassium hydroxide or Grams smear, or both Exclusion criteria: not specified |
|
Interventions |
All three drugs were prepared in an ointment base and were applied 5 times a day. Cycloplegics (atropine or homatropine), antiglaucoma medication (acetazolamide, glycerol) and vitamins (A, B complex and C) were given where indicated. |
|
Outcomes |
|
|
Notes | Funding: not reported Conflict of interest: not reported |
|
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | "The cases were divided into 3 treatment groups […] on a random basis” Page 573 |
Allocation concealment (selection bias) | Low risk | “The drugs […were] coded by the Ocular Pharmacology Laboratory” Page 573 “At the end of the trial, the code was broken and the result analyzed” Page 573 |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | “Each patient was given a coded antifungal ointment tube of 5g to be applied 5 times a day and the entire study was conducted in a double blind manner” Page 573 |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | “The drugs […were] coded by the Ocular Pharmacology Laboratory” Page 573 “Each patient was given a coded antifungal ointment tube of 5g to be applied 5 times a day and the entire study was conducted in a double blind manner” Page 573 “At the end of the trial, the code was broken and the result analyzed” Page 573 |
Incomplete outcome data (attrition bias) All outcomes | Low risk | “There was no fallout from this study on account of poor patient compliance” Page 573 |
Selective reporting (reporting bias) | Low risk | Probably not a problem as they reported ulcers responding to treatment |