Watcha 1995.

Methods	Randomized, double‐blind, placebo‐controlled study
Participants	ASA I or II children scheduled for brief, elective peripheral procedures (not involving body cavities) under general endotracheal anaesthesia. 113 participants were randomly allocated to placebo (37 participants), neostigmine (38 participants) and edrophonium groups (38 participants) Placebo group (N = 37 participants): age (y): 8.6 ± 4.3, weight (kg): 35.7 ± 24.4, surgical time (min): 56 ± 38, anaesthetic time (min): 106 ± 48 Neostigmine group (N = 38 participants): age (y): 9.4 ± 4.8, weight (kg): 37.2 ± 23.6, surgical time (min): 69 ± 47, anaesthetic time (min): 117 ± 56 (Values are mean ± SD)
Interventions	Neostigmine: 70 μg/kg with glycopyrrolate 10 μg/kg in 10 ml Placebo: 10 ml saline At the end of surgical procedure, participants received one of the drugs
Outcomes	Lowest oxyhaemoglobin saturation by pulse oximetry (%): neostigmine 97.6 ± 1.8, placebo 98.5 ± 2.5 Risk of postoperative emesis in PACU (%): neostigmine 34, placebo 11 (P value < 0.05) Risk of postoperative emesis without analgesic therapy in PACU (%): neostigmine 36, placebo 10 (P value 0.04) Risk of overall 24‐hour emesis (%): neostigmine 54, placebo 44 (Values are mean ± SD)
Notes	We placed the study in 'awaiting classification' because some of the children in the study are older than 12 years (our inclusion criterion is younger than 12 years of age, including newborns). We wrote to the study author to request relevant information in February 2013, but as yet have not received a reply

Abbreviations:

PACU: Postanaesthesia care unit.