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. 2024 Mar 1;29:151. doi: 10.1186/s40001-024-01742-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — TR4 promotes pyroptosis during urosepsis. A Propidium iodide (PI; red indicates dead cells) and Hoechst (blue indicates all nuclei) double staining were used to observe the morphology of pyroptotic cell, and the numbers of pyroptotic cells were compared; *p < 0.05, **p < 0.01, ***p < 0.001. B Comparison of the IL-1β concentration in the culture supernatant of control and TR4-overexpressing macrophages; *p < 0.05, **p < 0.01, ***p < 0.001. C Comparison of 24-h pyroptotic cell numbers in control and TR4-overexpressing macrophages