Table 3.

Common ADC payloads

Type of toxic payload	Payload	Representative tumor-targeting ADCs
Microtubule-targeting payload	Maytansinoids	PF-06647020
	Auristatin	IMGN901, MRG003, Teliso-V, BA3011 TIVDAK, Glembatumumab vedotin, Tisotumab vedotin, EnaV
	Eribulin	BB-1701
	Tubulysins	EC1428
	Cryptophycins	Dictyostatin
	EG5 inhibitors	–
DNA-targeting payload	Enediyne	Loncastuximab tesirine-lpyl
	Topoisomerase I inhibitors	DXd
	PBD	Zynlonta
	Duocarmycins	Trastuzumab duocarmazine
RNA-targeting payload	Thailanstatin	MC-Thailanstatin A
	Amatoxins	–
Immune agonist	Toll-like receptor agonists	BDC-1001, Silverback
	STING agonists	XMT-2056
	Glucocorticoid receptor modulators	ABBV-319

ADC antibody drug conjugate, PBD pyrrolobenzodiazepines