Table 4.

Common PDC payloads

Type of toxic payload	Payload	Representative tumor-targeting PDCs
Chemical drug	Paclitaxel	Paclitaxel-poly(L-lysine) conjugate (PTX–PLL), ImmunoGen 853
	Amanitin	Adcetris, Kadcyla, Mirvetuximab soravtansine
	Doxorubicin	TAT-doxorubicin, RGD-doxorubicin
	MTX	Glembatumumab vedotin, NPY-MTX conjugate
	Cathinone	ALOS4-camptothecin conjugate, SG3199
	Phenylbutyric acid nitrogen mustard	Benzenebutanoic acid nitrogen mustard–AAAk conjugate, EMD 525797
Nonchemical drug	TNF	NGR–hTNF, Etanercept, Infliximab
	siRNA	cRGD–siEGFR, Atu027
	AONs	Pip-AONs, AVI-4126

MTX methotrexate