Table 7.

Constituents of ADCs used in lung cancer treatment

ADC drug name	Payload	Linker	Antibody
T-DM1	Emtansine	Thioether linker	Trastuzumab
T-DXd	Deruxtecan	DXd linker	Trastuzumab
ADCT-402	Pyrrolobenzodiazepine	Di-thiomaleimides	Loncastuximab tesirine
HER3-DXd	Deruxtecan	Tetrapeptide linker	Patritumab
MRG003	MMAE	Val–Cit	MMAE
Teliso-V	MMAE	Mc-vc-PAB	ABT-700
DS-1062a	Topoisomerase I inhibitor	Tetrapeptide linker	Datopotamab
IMMU-132	Topoisomerase I inhibitor	CL2A linker	Sacituzumab
ABBV-399	MMAE	Valine glutamic acid linker	ABT-700
ABBV-181	PBD dimer	Val-Ala linker	DLL3 antibody
Rova-T	PBD	Mc-vc-PAB linker	SC16
BA3011	MMAE	Val–Cit	Sggc-Fc
TIVDAK	MMAE	Enzyme-sensitive linker	TF antibody
PF-06647020	Auristatin-0101	Val–Cit	Cofetuzumab
SAR-408701	DM4	SPDB	SAR408377
XMT-1536	MMAF	Succinimidyl 4-(N-maleimidomethyl) Cyclohexane-1-carboxylate	NaPi2b antibody
XMT-1592	MMAF	Dolasynthen	NaPi2b antibody
MRG003	MMAE	Val–Cit	EGFR antibody
MGC018	Docamycin	Val–Cit	Omburtamab
CX-2009	DM4	Enzyme-sensitive linker	Praluzatamab
IMGN901	Maytansine DM1	Cleavable SPP linker	CD30 antibody
XMT-1522	MMAF	Fleximer polymer linker	HT-19
SG	SN-38	Noncleavable linker	Sacituzumab
Glembatumumab vedotin	MMAE	Mc-vc-PAB	Glembatumumab
Anetumab ravtansine	DM4	Cyclohexane-1-carboxylate	MF-T
Tisotumab vedotin	MMAE	Enzyme-sensitive linker	TF-011
EnaV	MMAE	Mc-vc-PAB	AXL-107
BL-B01D1	ED04	Enzyme-sensitive linker	EGFR and HER3 antibody
SYSA1801	LND002	pH-sensitive linker	CLDN18.2 antibody
TORL-1–23	MMAE	Val–Cit	CLDN6 antibody
CBP-1008	MMAE	MC-VC	FRα and TRPV6 antibody
ABBV-221	MMAE	Val–Cit	EGFR antibody
PF-06263507	MMAE	MC linker	TPBG antibody
BMS-986148	Duocarmycin	Val–Cit	MSLN antibody

MMAE monomethyl auristatin E, MMAF monomethyl auristatin F, PBD pyrrolobenzodiazepines